Adeno-Associated Virus–Mediated IL-10 Gene Transfer Suppresses Lacrimal Gland Immunopathology in a Rabbit Model of Autoimmune Dacryoadenitis

PURPOSE. To evaluate the effect of adeno-associated virus (AAV) vector–mediated viral (v)IL-10 gene expression on lacrimal gland (LG) immunopathology and ocular surface disease in a rabbit model of induced autoimmune dacryoadenitis (ID). METHODS. Autologous peripheral blood lymphocytes, activated in...

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Detalhes bibliográficos
Main Authors: Thomas, Padmaja B., Samant, Deedar M., Selvam, Shivaram, Wei, Rui Hua, Wang, Yanru, Stevenson, Douglas, Schechter, Joel E., Apparailly, Florence, Mircheff, Austin K., Trousdale, Melvin D.
Formato: Artigo
Idioma:Inglês
Publicado em: Association for Research in Vision and Ophthalmology, Inc. 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066626/
https://ncbi.nlm.nih.gov/pubmed/20505195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5423
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