2′-Hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma

Renal cell carcinoma (RCC) is one of the top ten cancers prevalent in USA. Loss-of-function mutations in the von Hippel–Lindau (VHL) gene constitute an established risk factor contributing to 75% of total reported cases of RCC. Loss-of-VHL leads to a highly vascularized phenotype of renal tumors. In...

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Hauptverfasser: Nagaprashantha, Lokesh Dalasanur, Vatsyayan, Rit, Singhal, Jyotsana, Lelsani, Poorna, Prokai, Laszlo, Awasthi, Sanjay, Singhal, Sharad S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Cancer Prevention
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066423/
https://ncbi.nlm.nih.gov/pubmed/21304051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr021
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