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Transdermal Delivery of an Anti-Cancer Drug via W/O Emulsions Based on Alkyl Polyglycosides and Lecithin: Design, Characterization, and In Vivo Evaluation of the Possible Irritation Potential in Rats
The purpose of this work was to develop w/o emulsions that could be safely used to promote transdermal delivery of 5-fluorouracil (5-FU). Two pseudo-ternary phase diagrams comprising oleoyl-macrogol glycerides, water, and a surfactant/co-surfactant (S/CoS) mixture of lecithin, ethanol, and either co...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer US
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3066351/ https://ncbi.nlm.nih.gov/pubmed/21152999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9557-y |
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