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A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors

Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d-TC) are neurotoxins that have been highly instrumental in decades of research on glycine receptors (GlyR) and nicotinic ac...

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書誌詳細
主要な著者: Brams, Marijke, Pandya, Anshul, Kuzmin, Dmitry, van Elk, René, Krijnen, Liz, Yakel, Jerrel L., Tsetlin, Victor, Smit, August B., Ulens, Chris
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066128/
https://ncbi.nlm.nih.gov/pubmed/21468359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001034
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