Biological and immunological characterization of recombinant Yellow Fever 17D Viruses expressing a Trypanosoma cruzi Amastigote Surface Protein-2 CD8(+ )T cell epitope at two distinct regions of the genome

BACKGROUND: The attenuated Yellow fever (YF) 17D vaccine virus is one of the safest and most effective viral vaccines administered to humans, in which it elicits a polyvalent immune response. Herein, we used the YF 17D backbone to express a Trypanosoma cruzi CD8(+ )T cell epitope from the Amastigote...

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Main Authors: Nogueira, Raquel T, Nogueira, Alanderson R, Pereira, Mirian CS, Rodrigues, Maurício M, Galler, Ricardo, Bonaldo, Myrna C
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066119/
https://ncbi.nlm.nih.gov/pubmed/21418577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-127
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