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Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration
Poly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30) is an abundant nuclear enzyme, activated by DNA strand breaks to attach up to 200 ADP-ribose groups to nuclear proteins. As retroviral infection requires integrase-catalyzed DNA strand breaks, we examined infection of pseudotyped HIV type I in fibr...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC30659/ https://ncbi.nlm.nih.gov/pubmed/11248084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051633498 |
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