A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration

Vascular endothelial growth factor (VEGF) has two highly homologous tyrosine kinase receptors: Flt-1 (VEGFR-1) and KDR (VEGFR-2). KDR is strongly phosphorylated on tyrosines and can transmit mitogenic and motogenic signals following VEGF binding, while Flt-1 is markedly less effective in mediating s...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Gille, Hendrik, Kowalski, Joe, Yu, Lanlan, Chen, Helen, Pisabarro, M.Teresa, Davis-Smyth, Terri, Ferrara, Napoleone
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2000
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC306589/
https://ncbi.nlm.nih.gov/pubmed/10921887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.15.4064
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