Tissue Stretch Decreases Soluble TGF-β1 and Type-1 Procollagen in Mouse Subcutaneous Connective Tissue: Evidence From Ex Vivo and In Vivo Models

Transforming growth factor beta 1 (TGF-β1) plays a key role in connective tissue remodeling, scarring, and fibrosis. The effects of mechanical forces on TGF-β1 and collagen deposition are not well understood. We tested the hypothesis that brief (10 min) static tissue stretch attenuates TGF-β1-mediat...

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Detalhes bibliográficos
Main Authors: Bouffard, Nicole A., Cutroneo, Kenneth R., Badger, Gary J., White, Sheryl L., Buttolph, Thomas R., Ehrlich, H. Paul, Stevens-Tuttle, Debbie, Langevin, Helene M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065715/
https://ncbi.nlm.nih.gov/pubmed/17654495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21209
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