Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against HIV-1-B Nef by Inclusion of Epitope Variant Sequences

Different vaccine approaches cope with HIV-1 diversity, ranging from centralized(1–4) to variability-encompassing(5–7) antigens. For all these strategies, a concern remains: how does HIV-1 diversity impact epitope recognition by the immune system? We studied the relationship between HIV-1 diversity...

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Detalhes bibliográficos
Main Authors: Rolland, Morgane, Frahm, Nicole, Nickle, David C., Jojic, Nebojsa, Deng, Wenjie, Allen, Todd M., Brander, Christian, Heckerman, David E., Mullins, James I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065451/
https://ncbi.nlm.nih.gov/pubmed/21464919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017969
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