Declining brain activity in cognitively normal apolipoprotein E ɛ4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease

Cross-sectional positron emission tomography (PET) studies find that cognitively normal carriers of the apolipoprotein E (APOE) ɛ4 allele, a common Alzheimer's susceptibility gene, have abnormally low measurements of the cerebral metabolic rate for glucose (CMRgl) in the same regions as patient...

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Главные авторы: Reiman, Eric M., Caselli, Richard J., Chen, Kewei, Alexander, Gene E., Bandy, Daniel, Frost, Jennifer
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2001
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC30654/
https://ncbi.nlm.nih.gov/pubmed/11248079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061509598
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