Inhibition of angiogenic and non-angiogenic targets by sorafenib in renal cell carcinoma (RCC) in a RCC xenograft model

BACKGROUND: It is widely recognised that sorafenib inhibits a range of molecular targets in renal cell carcinoma (RCC). In this study, we aim to use patient-derived RCC xenografts to delineate the angiogenic and non-angiogenic molecular targets of sorafenib therapy for advanced RCC (aRCC). METHODS:...

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Bibliographische Detailangaben
Hauptverfasser: Yuen, J S P, Sim, M Y, Siml, H G, Chong, T W, Lau, W K O, Cheng, C W S, Huynh, H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065286/
https://ncbi.nlm.nih.gov/pubmed/21407223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.55
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