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Peyer's patches are required for oral tolerance to proteins

To clarify the role of Peyer's patches in oral tolerance induction, BALB/c mice were treated in utero with lymphotoxin β-receptor Ig fusion protein to generate mice lacking Peyer's patches. When these Peyer's patch-null mice were fed 25 mg of ovalbumin (OVA) before systemic immunization, OVA-specifi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Fujihashi, Kohtaro, Dohi, Taeko, Rennert, Paul D., Yamamoto, Masafumi, Koga, Toshiya, Kiyono, Hiroshi, McGhee, Jerry R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30650/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248075/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061412598
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