Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

The macrocyclic polyketides FK506, FK520, and rapamycin are potent immunosuppressants that prevent T-cell proliferation through initial binding to the immunophilin FKBP12. Analogs of these molecules are of considerable interest as therapeutics in both metastatic and inflammatory disease. For these p...

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Main Authors: Andexer, Jennifer N., Kendrew, Steven G., Nur-e-Alam, Mohammad, Lazos, Orestis, Foster, Teresa A., Zimmermann, Anna-Sophie, Warneck, Tony D., Suthar, Dipen, Coates, Nigel J., Koehn, Frank E., Skotnicki, Jerauld S., Carter, Guy T., Gregory, Matthew A., Martin, Christine J., Moss, Steven J., Leadlay, Peter F., Wilkinson, Barrie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064383/
https://ncbi.nlm.nih.gov/pubmed/21383123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015773108
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