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PKR-dependent CHOP induction limits hyperoxia-induced lung injury

Supplemental O(2) is commonly employed in patients with respiratory failure; however, hyperoxia is also a potential contributor to lung injury. In animal models, hyperoxia causes oxidative stress in the lungs, resulting in increased inflammation, edema, and permeability. We hypothesized that oxidati...

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Detalhes bibliográficos
Main Authors: Lozon, Tricia I., Eastman, Alison J., Matute-Bello, Gustavo, Chen, Peter, Hallstrand, Teal S., Altemeier, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064291/
https://ncbi.nlm.nih.gov/pubmed/21186267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00166.2010
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