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A New Autophagy-related Checkpoint in the Degradation of an ERAD-M Target

The endoplasmic reticulum (ER) harbors elaborate quality control mechanisms to ensure proper folding and post-translational modifications of polypeptides targeted to this organelle. Once an aberrant protein is detected, it is dislocated from the ER and routed to the proteasome for destruction. Autop...

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Autores principales: Kario, Edith, Amar, Nira, Elazar, Zvulun, Navon, Ami
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064203/
https://ncbi.nlm.nih.gov/pubmed/21228276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177618
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