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Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations

P2X7 receptors have emerged as potential drug targets for the treatment of medical conditions such as e.g. rheumatoid arthritis and neuropathic pain. To assess the impact of pharmaceuticals on P2X7, we screened a compound library comprising approved or clinically tested drugs and identified several...

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Main Authors: Nörenberg, Wolfgang, Hempel, Christoph, Urban, Nicole, Sobottka, Helga, Illes, Peter, Schaefer, Michael
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064161/
https://ncbi.nlm.nih.gov/pubmed/21262970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.198879
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