Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

OBJECTIVE: Insulin in pancreatic β-cells is a target of autoimmunity in type 1 diabetes. In the NOD mouse model of type 1 diabetes, oral or nasal administration of insulin induces immune tolerance to insulin and protects against autoimmune diabetes. Evidence for tolerance to mucosally administered i...

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Detalhes bibliográficos
Main Authors: Fourlanos, Spiros, Perry, Christine, Gellert, Shane A., Martinuzzi, Emanuela, Mallone, Roberto, Butler, Jeanne, Colman, Peter G., Harrison, Leonard C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064097/
https://ncbi.nlm.nih.gov/pubmed/21307076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1360
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