Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster

High blood concentration of the N-terminal cleavage product of the B-type natriuretic peptide (NT-proBNP) is strongly associated with cardiac dysfunction and is increasingly used for heart failure diagnosis. To identify genetic variants associated with NT-proBNP level, we performed a genome-wide ass...

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Detalhes bibliográficos
Main Authors: Del Greco M., Fabiola, Pattaro, Cristian, Luchner, Andreas, Pichler, Irene, Winkler, Thomas, Hicks, Andrew A., Fuchsberger, Christian, Franke, Andre, Melville, Scott A., Peters, Annette, Wichmann, H. Erich, Schreiber, Stefan, Heid, Iris M., Krawczak, Michael, Minelli, Cosetta, Wiedermann, Christian J., Pramstaller, Peter P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Association Studies Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063986/
https://ncbi.nlm.nih.gov/pubmed/21273288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr035
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