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Natural selection and functional genetic variation in the p53 pathway

The allele frequencies of two functional single-nucleotide polymorphisms (SNPs) in the p53 pathway, the MDM2 SNP309 and TP53 Arg72Pro, vary dramatically among populations. That the frequencies of the TP53 SNP follow a clinal distribution may suggest that selective pressure from environmental variabl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sucheston, Lara, Witonsky, David B., Hastings, Darcie, Yildiz, Ozlem, Clark, Vanessa J., Di Rienzo, Anna, Onel, Kenan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063984/
https://ncbi.nlm.nih.gov/pubmed/21266458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr028
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