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Natural selection and functional genetic variation in the p53 pathway
The allele frequencies of two functional single-nucleotide polymorphisms (SNPs) in the p53 pathway, the MDM2 SNP309 and TP53 Arg72Pro, vary dramatically among populations. That the frequencies of the TP53 SNP follow a clinal distribution may suggest that selective pressure from environmental variabl...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063984/ https://ncbi.nlm.nih.gov/pubmed/21266458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr028 |
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