Non-invasive Monitoring of L-2-Oxothiazolidine-4-Carboxylate Metabolism in the Rat Brain by In vivo (13)C Magnetic Resonance Spectroscopy

The cysteine precursor L-2-oxothiazolidine-4-carboxylate (OTZ, procysteine) can raise cysteine concentration, and thus glutathione levels, in some tissues. OTZ has therefore been proposed as a prodrug for combating oxidative stress. We have synthesized stable isotope labeled OTZ (i.e. L-2-oxo-[5-(13...

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Autori principali: Gamcsik, Michael P., Clark, M. Daniel, Ludeman, Susan M., Springer, James B., D’Alessandro, Michael A., Simpson, Nicholas E., Pourdeyhimi, Roxana, Johnson, C. Bryce, Teeter, Stephanie D., Blackband, Stephen J., Thelwall, Peter E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063897/
https://ncbi.nlm.nih.gov/pubmed/21161591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-010-0362-5
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