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Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

DNA ligase IV (Lig4) and the DNA-dependent protein kinase (DNA-PK) function in nonhomologous end joining (NHEJ). However, although Lig4 deficiency causes late embryonic lethality, deficiency in DNA-PK subunits (Ku70, Ku80, and DNA-PKcs) does not. Here we demonstrate that, similar to p53 deficiency,...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sekiguchi, JoAnn, Ferguson, David O., Chen, Hua Tang, Yang, Eva Mary, Earle, John, Frank, Karen, Whitlow, Scott, Gu, Yansong, Xu, Yang, Nussenzweig, André, Alt, Frederick W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30638/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248063/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051632098
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