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Use of Human Tissue to Assess the Oncogenic Activity of Melanoma-Associated Mutations
Multiple genetic alterations occur in melanoma, a lethal skin malignancy of increasing incidence1,2. These include mutations that activate Ras and two of its effector cascades, Raf and phosphoinositide 3-kinase (PI3K). Ras and Raf induction can occur via active N-Ras and B-Raf mutants as well as by...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063773/ https://ncbi.nlm.nih.gov/pubmed/15951821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1586 |
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