Endothelial Endothelin B Receptor-Mediated Prevention of Cerebrovascular Remodeling Is Attenuated in Diabetes Because of Up-Regulation of Smooth Muscle Endothelin Receptors

Structure and function of the cerebrovasculature is critical for ischemic stroke outcome. We showed that diabetes causes cerebrovascular remodeling by activation of the endothelin A (ET(A)) receptors. The goal of this study was to test the hypotheses that vasculoprotective endothelial ET(B) receptor...

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Autors principals: Kelly-Cobbs, Aisha I., Harris, Alex K., Elgebaly, Mostafa M., Li, Weiguo, Sachidanandam, Kamakshi, Portik-Dobos, Vera, Johnson, Maribeth, Ergul, Adviye
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2011
Matèries:
Cardiovascular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063745/
https://ncbi.nlm.nih.gov/pubmed/21205912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175380
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