Administration of a Synthetic TLR4 Agonist Protects Mice from Pneumonic Tularemia

Francisella tularensis is a Gram-negative intracellular pathogen that causes the zoonosis tularemia. Because F. tularensis LPS causes weak TLR4 activation, we hypothesized that administration of a synthetic TLR4 agonist, aminoalkyl glucosaminide phosphate (AGP), would boost the innate immune system...

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Hlavní autoři: Lembo, Annalisa, Pelletier, Mark, Iyer, Ravi, Timko, Michele, Dudda, Jan C., West, T. Eoin, Wilson, Christopher B., Hajjar, Adeline M., Skerrett, Shawn J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063511/
https://ncbi.nlm.nih.gov/pubmed/18490759
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