TLR signaling is required for virulence of an intracellular pathogen

Toll-like receptors (TLRs) contribute to host resistance to microbial pathogens and drive the evolution of virulence mechanisms. We have examined the relationship between host resistance and pathogen virulence using mice with a functional allele of the Nramp-1 gene and lacking combinations of TLRs....

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Main Authors: Arpaia, Nicholas, Godec, Jernej, Lau, Laura, Sivick, Kelsey E., McLaughlin, Laura M., Jones, Marcus B., Dracheva, Tatiana, Peterson, Scott N., Monack, Denise M., Barton, Gregory M.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063366/
https://ncbi.nlm.nih.gov/pubmed/21376231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.01.031
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