TLR signaling is required for virulence of an intracellular pathogen

Toll-like receptors (TLRs) contribute to host resistance to microbial pathogens and drive the evolution of virulence mechanisms. We have examined the relationship between host resistance and pathogen virulence using mice with a functional allele of the Nramp-1 gene and lacking combinations of TLRs....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Arpaia, Nicholas, Godec, Jernej, Lau, Laura, Sivick, Kelsey E., McLaughlin, Laura M., Jones, Marcus B., Dracheva, Tatiana, Peterson, Scott N., Monack, Denise M., Barton, Gregory M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063366/
https://ncbi.nlm.nih.gov/pubmed/21376231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.01.031
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