Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma

Hypermethylation of the promoter region of tumor-related genes (TRGs) has been shown to silence gene expression during melanoma progression, whereas microRNA-29(miR-29) has been found to downregulate DNA methyltransferases DNMT3A and DNMT3B which were shown as essential to the methylation of TRGs. W...

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Detalhes bibliográficos
Main Authors: Nguyen, Tung, Kuo, Christine, Nicholl, Michael B, Sim, Myung-Shin, Turner, Roderick R, Morton, Donald L, Hoon, Dave S.B
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063331/
https://ncbi.nlm.nih.gov/pubmed/21081840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.6.3.14056
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