Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

Platelet-derived growth factor (PDGF) plays critical roles in mesangial cell (MC) proliferation in mesangial proliferative glomerulonephritis. We showed previously that Smad1 contributes to PDGF-dependent proliferation of MCs, but the mechanism by which Smad1 is activated by PDGF is not precisely kn...

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Main Authors: Mima, Akira, Abe, Hideharu, Nagai, Kojiro, Arai, Hidenori, Matsubara, Takeshi, Araki, Makoto, Torikoshi, Kazuo, Tominaga, Tatsuya, Iehara, Noriyuki, Fukatsu, Atsushi, Kita, Toru, Doi, Toshio
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062564/
https://ncbi.nlm.nih.gov/pubmed/21445358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017929
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