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Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain

Mammalian homologues of Drosophila Trp form plasma membrane channels that mediate Ca(2+) influx in response to activation of phospholipase C and internal Ca(2+) store depletion. Previous studies showed that human Trp3 is activated by inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) and ident...

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Detalhes bibliográficos
Main Authors: Zhang, Zongming, Tang, Jisen, Tikunova, Svetlana, Johnson, J. David, Chen, Zhangguo, Qin, Ning, Dietrich, Alexander, Stefani, Enrico, Birnbaumer, Lutz, Zhu, Michael Xi
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30625/
https://ncbi.nlm.nih.gov/pubmed/11248050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051632698
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