The host genomic environment of the provirus determines the abundance of HTLV-1–infected T-cell clones

Human T-lymphotropic virus type 1 (HTLV-1) persists by driving clonal proliferation of infected T lymphocytes. A high proviral load predisposes to HTLV-1–associated diseases. Yet the reasons for the variation within and between persons in the abundance of HTLV-1–infected clones remain unknown. We de...

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Autors principals: Gillet, Nicolas A., Malani, Nirav, Melamed, Anat, Gormley, Niall, Carter, Richard, Bentley, David, Berry, Charles, Bushman, Frederic D., Taylor, Graham P., Bangham, Charles R. M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062313/
https://ncbi.nlm.nih.gov/pubmed/21228324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-312926
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