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Aging induces a distinct gene expression program in mouse islets
The role of aging in the pathogenesis of type 2 diabetes remains poorly understood. In the past adult β-cells were assumed to undergo frequent turnover. However, we find that β-cell turnover declines to very low levels in middle-aged mice. We therefore hypothesized that aged islets could exhibit a d...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Landes Bioscience
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062249/ https://ncbi.nlm.nih.gov/pubmed/21099336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.2.6.13376 |
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