Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

BACKGROUND: We previously showed that microglia damage blood brain barrier (BBB) components following ischemic brain insults, but the underlying mechanism(s) is/are not well known. Recent work has established the contribution of toll-like receptor 4 (TLR4) activation to several brain pathologies inc...

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Bibliographic Details
Main Authors: Kacimi, Rachid, Giffard, Rona G, Yenari, Midori A
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061894/
https://ncbi.nlm.nih.gov/pubmed/21385378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-8-7
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