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Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate.

Novel analogues of P1,P4-bis(5'-adenosyl) tetraphosphate, Ap4A (1), have been prepared with sulphur substituents at P1 and P4 and either oxygen or methylene bridges at the P2,P3-position. Separation of three isomers of the ApspCH2ppsA species has been achieved by a combination of mplc and hplc...

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Main Authors: Blackburn, G M, Taylor, G E, Thatcher, G R, Prescott, M, McLennan, A G
Format: Artigo
Jezik:Inglês
Izdano: 1987
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC306188/
https://ncbi.nlm.nih.gov/pubmed/2821489
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