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Cadmium Induced p53-Dependent Activation of Stress Signaling, Accumulation of Ubiquitinated Proteins, and Apoptosis in Mouse Embryonic Fibroblast Cells

The tumor suppressor oncoprotein, p53, is a critical regulator of stress-induced growth arrest and apoptosis. p53 activity is regulated through the ubiquitin proteasome system (UPS) with stress-induced disruption leading to increased accumulation of p53, resulting in growth arrest. In the present st...

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Main Authors: Yu, Xiaozhong, Sidhu, Jaspreet S., Hong, Sungwoo, Robinson, Joshua F., Ponce, Rafael A., Faustman, Elaine M.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061482/
https://ncbi.nlm.nih.gov/pubmed/21252392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr010
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