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Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice

Pre-synaptic nerve terminals require high levels of ATP for the maintenance of synaptic function. Failure of synaptic mitochondria to generate adequate ATP has been implicated as a causative event preceding loss of synaptic networks in neurodegenerative disease. Endogenous oxidative stress has often...

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Detalhes bibliográficos
Main Authors: Flynn, James M., Choi, Sung W., Day, Nicholas U., Gerencser, Akos A., Hubbard, Alan, Melov, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061438/
https://ncbi.nlm.nih.gov/pubmed/21215798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.12.030
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