Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease

BACKGROUND: The non-pathogenic course of SIV infection in its natural host is characterized by robust viral replication in the absence of chronic immune activation and T cell proliferation. In contrast, acutely lethal enteropathic SIVsmm strain PBj induces a strong immune activation and causes a sev...

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Bibliografiske detaljer
Main Authors: Tschulena, Ulrich, Sanzenbacher, Ralf, Mühlebach, Michael D, Berger, André, Münch, Jan, Schindler, Michael, Kirchhoff, Frank, Plesker, Roland, Coulibaly, Cheick, Panitz, Sylvia, Prüfer, Steffen, Muckenfuss, Heide, Hamdorf, Matthias, Schweizer, Matthias, Cichutek, Klaus, Flory, Egbert
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060844/
https://ncbi.nlm.nih.gov/pubmed/21366921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-14
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