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Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease
BACKGROUND: The non-pathogenic course of SIV infection in its natural host is characterized by robust viral replication in the absence of chronic immune activation and T cell proliferation. In contrast, acutely lethal enteropathic SIVsmm strain PBj induces a strong immune activation and causes a sev...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060844/ https://ncbi.nlm.nih.gov/pubmed/21366921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-14 |
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