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Crystal structure of cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

Cytochrome P450 14α-sterol demethylases (CYP51) are essential enzymes in sterol biosynthesis in eukaryotes. CYP51 removes the 14α-methyl group from sterol precursors such as lanosterol, obtusifoliol, dihydrolanosterol, and 24(28)-methylene-24,25-dihydrolanosterol. Inhibitors of CYP51 include triazol...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Podust, Larissa M., Poulos, Thomas L., Waterman, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30608/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248033/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061562898
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