The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.

We have detected amplified human Ki-ras sequences in tumorigenic NIH 3T3 cells transfected with genomic DNA from the human breast carcinoma cell line MDA-MB231. Hybridization of synthetic oligonucleotides specific for human Ki-ras sequences showed a mutation at codon 13. The polymerase chain reactio...

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Bibliographische Detailangaben
Hauptverfasser: Kozma, S C, Bogaard, M E, Buser, K, Saurer, S M, Bos, J L, Groner, B, Hynes, N E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1987
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC306061/
https://ncbi.nlm.nih.gov/pubmed/3627975
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