Genetic Variation in the Beta 2 Subunit of the Voltage-Gated Calcium Channel (CACNB2) and Pharmacogenetic Association with Adverse Cardiovascular Outcomes in the International Verapamil SR-Trandolapril Study-Genetic Substudy (INVEST-GENES)

BACKGROUND: Polymorphisms (SNPs) within the regulatory β2 subunit of the voltage-gated calcium channel (CACNB2) may contribute to variable treatment response to antihypertensive drugs and adverse cardiovascular outcomes. METHODS AND RESULTS: SNPs in CACNB2 from 60 ethnically diverse individuals were...

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Autores principales: Niu, Yuxin, Gong, Yan, Langaee, Taimour Y., Davis, Heather M., Elewa, Hazem, Beitelshees, Amber L., Moss, James I., Cooper-DeHoff, Rhonda M., Pepine, Carl J., Johnson, Julie A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060561/
https://ncbi.nlm.nih.gov/pubmed/21156931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.110.957654
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