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Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion

Pancreatic ductal adenocarcinoma (PDAC) is characterized by pronounced fibrotic reaction composed primarily of type I collagen. Although type I collagen functions as a barrier to invasion, pancreatic cancer cells have been shown to respond to type I collagen by becoming more motile and invasive. Bec...

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Bibliographische Detailangaben
Hauptverfasser: Shields, Mario A., Dangi-Garimella, Surabhi, Krantz, Seth B., Bentrem, David J., Munshi, Hidayatullah G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060503/
https://ncbi.nlm.nih.gov/pubmed/21288898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195628
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