An Essential Role of the Cysteine-rich Domain of FZD4 in Norrin/Wnt Signaling and Familial Exudative Vitreoretinopathy

The Wnt pathway plays important yet diverse roles in health and disease. Mutations in the Wnt receptor FZD4 gene have been confirmed to cause familial exudative vitreoretinopathy (FEVR). FEVR is characterized by incomplete vascularization of the peripheral retina, which can lead to vitreous bleeding...

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Hlavní autoři: Zhang, Kang, Harada, Yuko, Wei, Xinran, Shukla, Dhananjay, Rajendran, Anand, Tawansy, Khaled, Bedell, Matthew, Lim, Sharon, Shaw, Peter X., He, Xi, Yang, Zhenglin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060474/
https://ncbi.nlm.nih.gov/pubmed/21177847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194399
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