An Essential Role of the Cysteine-rich Domain of FZD4 in Norrin/Wnt Signaling and Familial Exudative Vitreoretinopathy

The Wnt pathway plays important yet diverse roles in health and disease. Mutations in the Wnt receptor FZD4 gene have been confirmed to cause familial exudative vitreoretinopathy (FEVR). FEVR is characterized by incomplete vascularization of the peripheral retina, which can lead to vitreous bleeding...

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Main Authors: Zhang, Kang, Harada, Yuko, Wei, Xinran, Shukla, Dhananjay, Rajendran, Anand, Tawansy, Khaled, Bedell, Matthew, Lim, Sharon, Shaw, Peter X., He, Xi, Yang, Zhenglin
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060474/
https://ncbi.nlm.nih.gov/pubmed/21177847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194399
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