Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning

Human data on protein binding and dose-dependent changes in toxicokinetics for MCPA are very limited. 128 blood samples were obtained in 49 patients with acute MCPA poisoning and total and unbound concentrations of MCPA were determined. The Scatchard plot was biphasic suggesting protein binding to t...

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Detalhes bibliográficos
Main Authors: Roberts, Darren M., Dawson, Andrew H., Senarathna, Lalith, Mohamed, Fahim, Cheng, Ron, Eaglesham, Geoffrey, Buckley, Nick A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060340/
https://ncbi.nlm.nih.gov/pubmed/21256202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2011.01.011
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