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SYSTEMATIC BIOCHEMICAL ANALYSIS OF SOMATIC MISSENSE MUTATIONS IN DNA POLYMERASE β FOUND IN PROSTATE CANCER REVEAL ALTERATION OF ENZYMATIC FUNCTION
DNA polymerase β is essential for short-patch base excision repair. We have previously identified 20 somatic pol β mutations in prostate tumors, many of them missense. In the current paper we describe the effect of all of these somatic missense pol β mutations (p.K27N, p.E123K, p.E232K, p.P242R, p.E...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060284/ https://ncbi.nlm.nih.gov/pubmed/21305655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21465 |
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