Gene Expression Alterations in Immune System Pathways in the Thymus after Exposure to Immunosuppressive Chemicals

BACKGROUND: Dysregulation of positive and negative selection, antigen presentation, or apoptosis in the thymus can lead to immunosuppression or autoimmunity. Diethylstilbestrol (DES), dexamethasone (DEX), cyclophosphamide (CPS), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are immunosuppressive ch...

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Main Authors: Frawley, Rachel, White, Kimber, Brown, Ronnetta, Musgrove, Deborah, Walker, Nigel, Germolec, Dori
Format: Artigo
Jezik:Inglês
Izdano: National Institute of Environmental Health Sciences 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060001/
https://ncbi.nlm.nih.gov/pubmed/21041162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1002358
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