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Solution structure of the antiapoptotic protein bcl-2

The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined by using Bcl-2/Bcl-x(L) chimeras in which part of the putative unstructured loop of Bcl-2 was replaced w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Petros, Andrew M., Medek, Ales, Nettesheim, David G., Kim, Daniel H., Yoon, Ho Sup, Swift, Kerry, Matayoshi, Edmund D., Oltersdorf, Tilman, Fesik, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30598/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248023/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.041619798
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