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Backbone and Side-Chain Contributions in Protein Denaturation by Urea
Urea is a commonly used protein denaturant, and it is of great interest to determine its interaction with various protein groups to elucidate the molecular basis of its effect on protein stability. Using the Trp-cage miniprotein as a model system, we report what we believe to be the first computatio...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059734/ https://ncbi.nlm.nih.gov/pubmed/21402035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.028 |
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