Identification of SPRED2 (Sprouty-related Protein with EVH1 Domain 2) as a Negative Regulator of the Hypothalamic-Pituitary-Adrenal Axis

Sprouty-related proteins with EVH1 (enabled/vasodilator-stimulated phosphoprotein homology 1) domain (SPREDs) are inhibitors of MAPK signaling. To elucidate SPRED2 in vivo function, we characterized body homeostasis in SPRED2(−/−) mice. They showed a doubled daily water uptake, induced by elevated s...

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Detalhes bibliográficos
Main Authors: Ullrich, Melanie, Bundschu, Karin, Benz, Peter M., Abesser, Marco, Freudinger, Ruth, Fischer, Tobias, Ullrich, Julia, Renné, Thomas, Walter, Ulrich, Schuh, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059030/
https://ncbi.nlm.nih.gov/pubmed/21199868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.171306
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