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A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function

The Aβ-precursor protein (APP) intracellular domain is highly conserved and contains many potentially important residues, in particular the (682)YENPTY(687) motif. To dissect the functions of this sequence in vivo, we created an APP knock-in allele mutating Tyr(682) to Gly (Y682G). Crossing this all...

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Detalhes bibliográficos
Main Authors: Barbagallo, Alessia P. M., Wang, Zilai, Zheng, Hui, D'Adamio, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059018/
https://ncbi.nlm.nih.gov/pubmed/21266574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.219873
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