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ESCRT-0 Assembles as a Heterotetrameric Complex on Membranes and Binds Multiple Ubiquitinylated Cargoes Simultaneously

The ESCRT machinery consists of multiple protein complexes that collectively participate in the biogenesis of multivesicular endosomes (MVEs). The ESCRT-0 complex is composed of two subunits, Hrs and STAM, both of which can engage ubiquitinylated substrates destined for lysosomal degradation. Here,...

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Bibliografiska uppgifter
Huvudupphovsmän: Mayers, Jonathan R., Fyfe, Ian, Schuh, Amber L., Chapman, Edwin R., Edwardson, J. Michael, Audhya, Anjon
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058970/
https://ncbi.nlm.nih.gov/pubmed/21193406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.185363
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