Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated molecules and recently has been shown to influence IL-1β secretion by macrophages. However, the mechanisms behind this are unclear. Here, we describe a novel role for autophagy in regulating the product...

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Autori principali: Harris, James, Hartman, Michelle, Roche, Caitrionna, Zeng, Shijuan G., O'Shea, Amy, Sharp, Fiona A., Lambe, Eimear M., Creagh, Emma M., Golenbock, Douglas T., Tschopp, Jurg, Kornfeld, Hardy, Fitzgerald, Katherine A., Lavelle, Ed C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058966/
https://ncbi.nlm.nih.gov/pubmed/21228274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.202911
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