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Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic anti-myeloma effect
Signaling through the receptor/transcriptional regulator Notch pathway plays an important role in tumor cell survival. Recent studies have demonstrated that pharmacological inhibition of the Notch pathway with γ-secretase inhibitor (GSI) induces apoptosis of multiple myeloma (MM) cells via up-regula...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058809/ https://ncbi.nlm.nih.gov/pubmed/21159606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0372 |
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